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EFFICACY OF DIAZOXIDE IN PREVENTING HYPOGLYCEMIA IN A CHILD AFFECTED BY HYPOPITUITARY DWARFISM
Author(s) -
VENTURA A.,
CANCIANI M.,
TAMARO P.
Publication year - 1983
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1983.tb09719.x
Subject(s) - medicine , diazoxide , hypoglycemia , dwarfism , endocrinology , growth hormone , insulin , hypopituitarism , drug , growth hormone deficiency , hormone , pharmacology , gene , biochemistry , chemistry
. An observation is reported of the efficacy of diazoxide (10 mg/kg/24 h) in the prevention of hypoglycemic crises in a child with growth hormone deficiency. The success of the therapy may be attributed to a reduction of glucose uptake induced by the drug, rather than to the inhibition of insulin secretion which is already depressed in subjects affected by growth hormone deficiency. The availability of a drug with no serious and irreversible side effects, capable of preventing hypoglycemic crises in patients with hormone deficiency, seems to be important whenever it is not possible to immediately start a replacement therapy.