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IMMUNOLOGICAL STUDIES IN TWO CHILDREN WITH RECURRENT PAROTITIS
Author(s) -
FRIIS B.,
PEDERSEN F. KARUP,
SCHIØDT M.,
WIIK A.,
HØJ L.,
ANDERSEN V.
Publication year - 1983
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1983.tb09709.x
Subject(s) - medicine , parotitis , anti nuclear antibody , pathogenesis , pathology , enteropathy , complement fixation test , antibody , immunology , salivary gland , autoantibody , immune system , serology , disease , dentistry
. In two children with recurrent parotitis, labial salivary gland biopsies showed chronic sialoadenitis. Immunofluorescence studies disclosed deposits of immunoglobulins and complement in juxta‐acinar small vessels. Case 1 had gluten enteropathy, IgA deficiency and high titres of antinuclear antibodies (ANA), and in vivo fixation of ANA to nuclei of different cells in lip, skin and jejunum was present. Case 2 showed deposition of IgM in the dermo‐epidermal junction of the skin. These findings suggest that autoimmune reactivity and immune complexes may play a role in the pathogenesis of this disorder.