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DEVELOPMENT OF GLOMERULAR FILTRATION RATE AND EXCRETION OF β 2 ‐MICROGLOBULIN IN NEONATES DURING GENTAMICIN TREATMENT
Author(s) -
ELINDER G.,
APERIA A.
Publication year - 1983
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1983.tb09701.x
Subject(s) - medicine , renal function , gentamicin , nephrotoxicity , excretion , gestational age , urine , renal physiology , reabsorption , endocrinology , beta 2 microglobulin , urology , kidney , pregnancy , antibiotics , biochemistry , chemistry , biology , genetics
. Ten infants of different gestational ages (GA) and postnatal ages (PNA), treated with gentamicin, were compared with 10 control patients of similar GA and PNA to evaluate the possible nephrotoxic effects of this drug. Changes in the glomerular filtration rate (GFR) and the fractional excretion of β 2 ‐microglobulin in urine (FEβ) were used as indicators of renal dysfunction. In the control infants there was a postnatal increase in the GFR that was higher in full‐term than in preterm infants. The FEβ decreased logarithmically as a function of both the GA and the PNA. The GFR was statistically lower in 5/10 and 6/10 of the patients on the first and the last days of gentamicin treatment (GT) respectively. Three weeks after GT, 8/10 had a normal GFR. The FEβ was statistically higher in 4/10 of the patients on their first day of GT and 7/10 on their last day of GT. Three weeks after GT, 9/10 of the patients had a normal FEβ for their postnatal and gestational ages. It is concluded that GT influences filtration and proximal reabsorption in GT infants by decreasing the GFR and increasing the FEβ. However, the observed renal dysfunction seemed to be reversible.