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THE EFFECTS OF COLESTIPOL HYDROCHLORIDE ON SERUM LIPOPROTEIN LIPID AND APOLIPOPROTEIN B AND A‐I CONCENTRATIONS IN CHILDREN HETEROZYGOUS FOR FAMILIAL HYPERCHOLESTEROLEMIA
Author(s) -
GROOT P. H. E.,
DIJKHUISSTOFFELSMA R.,
GROSE W. F. A.,
AMBAGTSHEER J. J.,
FERNANDES J.
Publication year - 1983
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1983.tb09668.x
Subject(s) - apolipoprotein b , medicine , endocrinology , familial hypercholesterolemia , lipoprotein , cholesterol , lipoprotein(a)
. Colestipol hydrochloride was administered to 28 children with familial hypercholesterolemia type II‐A, and its effects on serum lipoproteins were tested against a placebo in a cross‐over design. All children consumed a diet low in cholesterol and high in linoleic acid. Colestipol therapy resulted in a 15.7% decrease in serum very low plus low density lipoproteins and in a 13.5% decrease in serum apolipoprotein B. High density lipoprotein cholesterol, serum apolipoprotein A‐I and serum triglycerides remained unaltered.

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