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PLASMA AND URINARY β‐HEXOSAMINIDASE IN JUVENILE DIABETES MELLITUS
Author(s) -
HANSEUS K.,
HULTBERG B.,
ISAKSSON A.,
SJÖBLAD S.
Publication year - 1983
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1983.tb09667.x
Subject(s) - medicine , urinary system , endocrinology , diabetes mellitus , hexosaminidase , urine , juvenile , enzyme , biochemistry , biology , genetics
. The activity of β‐hexosaminidase (E C 3.2.1.30) in plasma and urine was determined in 99 patients with juvenile diabetes mellitus and in 40 age‐matched controls. Plasma enzyme activities were above normal in plasma from diabetics and showed significant correlations with blood glucose and glycosylated HbA 1 (GHbA 1 ) but not with the presence of retinopathy. The urinary excretion of β‐hexosaminidase, which is a sensitive indicator of renal injury, was also excessive in the diabetics and showed a significant correlation with blood GHbA 1 . The results show that plasma and urinary β‐hexosaminidase correlate with parameters of diabetic control and that urinary β‐hexosaminidase may be more sensitive than urinary albumin as an indicator of early renal damage.