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LINGUAL LIPASE Its role in lipid digestion in infants with low birthweight and/or pancreatic insufficiency
Author(s) -
FREDRIKZON B.,
HERNELL O.,
BLÄCKBERG L.
Publication year - 1982
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1982.tb09602.x
Subject(s) - lipase , lipolysis , lipid digestion , medicine , endocrinology , duodenum , digestion (alchemy) , exocrine pancreatic insufficiency , pancreas , enzyme , biochemistry , chemistry , adipose tissue , chromatography
Fredrikzon, B., Hernell, O. and Bläckberg, L. (Departments of Paediatrics and Physiological Chemistry, University of Umeå, Sweden). Lingual lipase. Its role in lipid digestion in infants with low birthweight and/or pancreatic insufficiency. Acta Paediatr Scand, Suppl. 296: 75, 1982.—At birth both pancreatic lipase and carboxylic ester hydrolase, two important lipolytic enzymes secreted by the pancreas, are present in duodenal contents but the activities of these enzymes are low. Another enzyme of possible importance in lipolysis is the lingual lipase which is secreted from serous glands present at the posterior part of the tongue. The enzyme is present already at birth and has been found in gastric contents from preterm infants in the 34th gestational week. The secretion of lingual lipase is stimulated by feeding and it is resistent against acid inactivation. The activity in gastric contents increases after feeding. This lipase hydrolyzes dietary triglycerides to mainly diglycerides and free fatty acids and may serve as a complement to the poorly developed pancreatic lipase activity. Furthermore, by the formation of polar lipolytic products the digestibility of dietary lipids in the duodenum may increase. Human milk lipase contributes to the lipolysis. It is inactive in the milk but becomes activated by the bile acids in the duodenum. Balance studies in preterm infants have shown that by pasteurization of human milk fat absorption decreases by one third.