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BLOOD LEVELS OF CRITICAL AMINO ACIDS IN VERY LOW BIRTHWEIGHT INFANTS ON A HIGH HUMAN MILK PROTEIN INTAKE
Author(s) -
LINDBLAD B. S.,
HAGELBERG S.,
LUNDSJÖ A.
Publication year - 1982
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1982.tb09589.x
Subject(s) - urea , medicine , amino acid , food science , biochemistry , endocrinology , biology
Lindblad, B. S., Hagelberg, S. and Lundsjö, A. (Department of Paediatrics, Karolinska Institute, St. Göran's Children's Hospital, Stockholm, Sweden). Blood levels of critical amino acids in very low birthweight infants on a high human milk protein intake. Acta Paediatr Scand, Suppl. 296: 24, 1982. — A method for a semi–industrial production of human milk subfractions (human milk protein and human milk fat isolates) is described. Four very low birthweight (VLBW) newborn were given a human milk protein isolate added to the mother's own fresh expressed milk in addition to sodium chloride up to 20 mEkv/liter. Growth followed the intrauterine growth curve. Urea levels did not increase in spite of providing a double‐normal protein intake. There was no metabolite acidosis and the blood levels of free amino acids determined with a micro‐method did not exceed those seen after a normal meal. The concentrated human milk protein product showed a considerable specific sIgA activity against E. coli 0‐antigen. It seems possible to use similar “lacto‐engineering”‐techniques in order to satisfy the increased protein requirements of the VLBW infant, while providing the caloric requirements, without causing any visible disturbance of blood‐homeostasis of urea, amino acids or base excess. The method could provide knowledge about the “human milk protein requirements” and a controlled study has been started.