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CONGENITAL PRIMARY HYPOTHYROIDISM AND HLA
Author(s) -
JACOBSEN B. BROCK,
BRANDT N. J.,
SVEJGAARD A.
Publication year - 1982
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1982.tb09549.x
Subject(s) - medicine , congenital hypothyroidism , human leukocyte antigen , thyroid , danish , ectopic thyroid , antigen , pediatrics , immunology , endocrinology , linguistics , philosophy
. Previous studies have suggested an association between congenital hypothyroidism and HLA‐Aw24 or B18 antigens. The frequencies of HLA‐A, B and C antigens were studied in 33 unrelated Danish patients with congenital hypothyroidism (5 with aplasia of the thyroid gland, 16 with ectopic thyroids and 8 with thyroid hyshormonogenesis). HLA‐Aw24 only appeared in patients with ectopic thyroids and HLA‐B18 was only seen in patients with dyshormonogenesis. However, the frequencies of HLA antigens in patients and in a large number of controls did not differ statistilly significantly. We conclude that HLA typing is without any predictive value in determining the risk of developing or giving birth to a child with congenital hypothyroidism.