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A FAMILY STUDY OF COELIAC DISEASE
Author(s) -
STENHAMMAR L.,
BRANDT Å.,
WÅGERMARK J.
Publication year - 1982
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1982.tb09486.x
Subject(s) - coeliac disease , medicine , malabsorption , biopsy , gastroenterology , first degree relatives , intestinal malabsorption , intestinal mucosa , disease , population , family history , pediatrics , environmental health
. Small intestinal biopsy was performed in all 100 firstdegree relatives of 32 index patients with childhood coeliac disease (CD) diagnosed according to the European Society for Paediatric Gastroenterology and Nutrition. CD was found in 2 relatives (2.0%), which means that first‐degree relatives of coeliac children would run a tenfold increased risk of CD compared with the general population of Sweden. Five relatives had a moderately abnormal mucosa. On rebiopsy they had a normal mucosa and are therefore not classified as having CD according to current diagnostic criteria. For practical purposes it would be impossible to perform a biopsy in all first‐degree relatives of coeliac patients. However, relatives with a past history of symptoms suggestive of malabsorption and relatives with present signs of malabsorption should be candidates for biopsy.