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HEMOSTATIC BALANCE ALTERATIONS IN OBESE CHILDREN
Author(s) -
CACCIARI E.,
COCCHERI S.,
BERGAMASCHI R.,
FORTUNATO G.,
BALSAMO A.,
POGGI M.,
CICOGNANI A.,
PIRAZZOLI P.,
ZAPPULLA F.
Publication year - 1982
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1982.tb09455.x
Subject(s) - medicine , balance (ability) , intensive care medicine , physical therapy
. Fibrinolytic response to venous occlusion and other clotting parameters were studied in 34 obese children and 16 controls. The obese children (mean age 9 2/12 years) had a mean overweight of 51.8%± 15.6, higher blood glucose and cholesterol levels, and increased baseline and glucoseinduced insulinemia. However, baseline ELT did not differ significantly; ELT after 5 min venous occlusion was 203.2 ± 110.9 min in the obese children and 114.7 ± 67.9 min in the control group ( p <0.01) with a mean percent decrease respectively of 14.9% and 29.2%. Poor fibrinolytic responders did not correlate with age, overweight, or metabolic indices. Lower levels of AT m ( p <0.01) and no changes in F VIII: C and F VIII: R Ag were also found in the obese. Furthermore, in a larger group of 84 prepubertal obese children (mean age 10 years; mean overweight 48.2%) and in 39 normal prepubertal children (mean age 10 4/12 years) we also studied platelet aggregation capacity according to Breddin. This parameter was altered in a high proportion of the obese children ( p <0.05). The obese children were also poor fibrinolytic responders, similarly to obese adults, and exhibited early alteration of the clotting balance.