Premium
NATURAL KILLER CELL ACTIVITY AND ANTIBODY‐DEPENDENT CELLULAR CYTOTOXICITY IN NEWBORN INFANTS
Author(s) -
HALLBERG A.,
MALMSTRÖM P.
Publication year - 1982
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1982.tb09447.x
Subject(s) - cytotoxicity , medicine , immunology , antibody , natural killer cell , cytotoxic t cell , lymphocyte , cell , biology , in vitro , biochemistry
. The ability of lymphocytes from the peripheral blood of preterm and term infants and adult women and men to mediate natural killing (NK) and K cell activity (antibody‐dependent cellular cytotoxicity) was analysed in 4 hours 51 Cr‐release assays. K 562 cells were targets for NK activity. K cell activity was assayed on antibody‐coated rat thymocytes. Lymphocytes from adult male donors were significantly more cytotoxic to K 562 cells than were lymphocytes from adult female donors. Lymphocytes from both preterm and term infants had significantly lower NK and K cell activity than lymphocytes from adult donors. During the first month of life no increase in NK activity or K cell activity occurred in 7 infants who were re‐examined. It is concluded that neither NK nor K cell activities are fully developed during the first month of life.