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THE EFFECT OF CHLORPROMAZINE IN SEVERE HYPOXIA IN NEWBORN INFANTS
Author(s) -
LARSSON L. E.,
EKSTRÖMJODAL B.,
HJALMARSON O.
Publication year - 1982
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1982.tb09441.x
Subject(s) - medicine , chlorpromazine , hypoxia (environmental) , vasodilation , anesthesia , respiratory distress , oxygenation , pneumonia , blood pressure , diaphragmatic hernia , congenital diaphragmatic hernia , fetus , cardiology , surgery , oxygen , hernia , pregnancy , genetics , chemistry , organic chemistry , biology
. Eighteen newborn infants with severe hypoxia during the course of idiopathic respiratory distress syndrome, pneumonia, persistent fetal circulation or right diaphragmatic hernia were treated with chlorpromazine with the aim of improving arterial oxygenation by a postulated vasodilatory action on the pulmonary circulation. Fourteen of the infants improved their P SO2 during the treatment. Nine infants died. The systematic arterial blood‐pressure and the urinary output were reduced and some infants were somnolent during the initial period of treatment. No other side effects were noted. Further studies of chlorpromazine as a possible pulmonary vasodilator in newborn infants are justified.