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METABOLIC CONTROL IN CHILDREN WITH INSULIN DEPENDENT DIABETES MELLITUS ASSESSED BY HEMOGLOBIN A 1c
Author(s) -
MORTENSEN H. B.,
VESTERMARK S.,
KASTRUP K. W.
Publication year - 1982
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1982.tb09402.x
Subject(s) - hemoglobin , metabolic control analysis , medicine , diabetes mellitus , hemoglobin a , insulin , diabetes control , endocrinology , physiology , pediatrics , type 2 diabetes
. The glycosylated hemoglobin component, hemoglobin A 1c , was estimated in 92 children with insulin dependent diabetes mellitus by an iso‐electric focusing procedure during an observation period of 18 months. A significant correlation between hemoglobin A 1c and the actual metabolic control according to clinical ratings was found. A seasonal variation in the concentration of the hemoglobin A 1c was observed with the lowest level in the months of June and July consistent with an improved metabolic control in the diabetic children during the summer period. A direct relationship was found between metabolic control as assessed by hemoglobin A 1c and retarded linear growth expressed as standard deviation score for height. Children with poorly controlled diabetes (intial hemoglobin A 1c level above 12.5%) improved their carbohydrate tolerance shown by a significantly lower glycohemoglobin level at the end of the observation period. Consequently, hemoglobin A 1c is particularly useful in the routine management of insulin dependent diabetic children in poor metabolic control. Frequent determinations are necessary since in these patients the glucose profiles are prone to great variations, which may lead to changes in the hemoglobin A 1c concentration of about 1% in a week.