Premium
TRACE METALS IN CYSTIC FIBROSIS
Author(s) -
CAILLIEBERTRAND M.,
BIÉVILLE F.,
NEIJENS H.,
KERREBIJN K.,
FERNANDES J.,
DEGENHART H.
Publication year - 1982
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1982.tb09400.x
Subject(s) - selenium , medicine , excretion , zinc , endocrinology , glutathione peroxidase , subclinical infection , cystic fibrosis , urinary system , gastroenterology , chemistry , oxidative stress , catalase , organic chemistry
. Serum zinc and copper concentration, 24 hrs urinary zinc and copper excretion, plasma selenium and red blood cell glutathione peroxidase activity were measured in 13 cystic fibrosis patients aged 6 to 15 years. The mean serum zinc value ± S. D. (17.3 μmol/1 ± 4.6) did not differ from that of the control group (17.9 μmol/1 ± 3.1). Urinary zinc excretion in 12 out of 13 patients was within the normal range (1.53‐13.8 μmol/24 hrs). The mean serum copper ± S. D. (23.8 μmol/1 ± 4.2) was not significantly elevated as compared to the value found in the control group (19.2 μmol/1 ± 3.5), but 4 children, including 1 with documented portal hypertension, showed an urinary copper excretion >0.94 μmol/24 hrs (normal: 0.16‐0.80 μmol/24 hrs). Mean plasma selenium ± S. D. (0.84 μmol/1 ± 0.25) was significantly reduced as compared to the control group (1.0 μmol/1 ± 0.15) ( p <0.05). The correlation between selenium concentration and RBC glutathione peroxidase activity was significant ( p <0.01). A negative correlation was also found between plasma selenium and 24 hrs faecal fat excretion ( p <0.05). It is concluded that CF children with severe dysfunction of the exocrine pancreas are at increased risk to develop symptoms of subclinical or manifest zinc and/or selenium deficiency. Appropriate supplementation should therefore systematically be considered.