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COMPARISON BETWEEN TWO PREPARATIONS OF HUMAN SERUM ALBUMIN IN TREATMENT OF NEONATAL HYPERBILIRUBINAEMIA
Author(s) -
EBBESEN F.,
BRODERSEN R.
Publication year - 1982
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1982.tb09376.x
Subject(s) - albumin , medicine , human serum albumin , bilirubin , serum albumin , human albumin , kernicterus , endocrinology , chromatography , chemistry
. Thirty‐six newborn infants with normal birth weights and with uncomplicated hyperbilirubinaemia, treated with light, were studied. At onset of phototherapy the infants received intravenously 1 g human serum albumin (HSA) per kg body weight as a 9 % solution. Two different preparations of HSA were used and compared. One of these, HSA I , contained sodium caprylate and N‐acetyltryptophan, 5 mmol/1 of each, as stabilizers. HSA II contained only caprylate, 5 mmol/1. Nineteen infants received HSA I and seventeen infants HSA II . The reserve albumin for binding of bilirubin, measured by the [ 14 C] MADDS method, was low in both preparations in vitro. During the infusion, the serum concentrations of albumin and reserve albumin increased and the serum unconjugated bilirubin concentration decreased, resulting in a fall in the index of plasma bilirubin toxicity in all infants. After completion of the infusion, the serum concentrations of albumin and reserve albumin declined, and a slight rise in index occurred. The increase in the serum reserve albumin concentration was markedly higher during infusion of HSA II than of HSA I . It is concluded that infusion of both HSA preparations during phototherapy provides an immediate protection against bilirubin encephalopathy. HSA I is inferior to HSA II , probably due to its content of N‐acetyltryptophan.