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THE ROLE OF ACTIVE SODIUM AND POTASSIUM TRANSPORT IN HYPONATREMIC STATES IN INFANCY AND CHILDHOOD
Author(s) -
SIGSTRöM L.
Publication year - 1981
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1981.tb16563.x
Subject(s) - hyponatremia , sodium , potassium , medicine , extracellular fluid , intracellular , extracellular , endocrinology , atpase , chemistry , biochemistry , enzyme , organic chemistry
. Sigström, L. (Department of Paediatrics I, University of Goteborg, östra Sjukhuset, Göteborg, Sweden). The role of active sodium and potassium transport in hyponatremia states in infancy and childhood. Acta Psediatr Scand, 70:353, 1981.–Erythrocytes from 14 infants and children with serum sodium concentrations of 125 mmol/1 or less were analyzed for total and Na + , K + ‐ATPase, sodium and potassium content and ATP concentrations to evaluate the role of active Na + ‐K + transport in hyponatremia. In six out of nine patients, with a duration of hyponatremia of more than 48 hours low Na + , K ‐ATPase activities and high erythrocyte sodium concentrations and Na + ‐K + ratios were found indicating that a decreased Na + , K + ‐ATPase activity leading to an increased intracellular accumulation of sodium ions may have reduced the extracellular sodium concentration. Three subjects with large sodium losses had high Na + , K + ‐ATPase activities and normal erythrocyte sodium concentrations. In five cases of hyponatremia with a duration of less than 24 hours the variables indicating active Na + ‐K + transport were normal. The therapeutic implications with sodium substitution and the use of drugs affecting active Na + ‐K + transport are discussed.