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PASSAGE OF CEPHALOSPORINS AND AMOXICILLIN INTO THE BREAST MILK
Author(s) -
KAFETZIS DIMITRIS A.,
SIAFAS CONSTANTINOS A.,
GEORGAKOPOULOS PANAGIOTIS A.,
PAPADATOS CONSTANTINOS J.
Publication year - 1981
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1981.tb16553.x
Subject(s) - medicine , cephalosporin , amoxicillin , breast milk , microbiology and biotechnology , antibiotics , biochemistry , chemistry , biology
ABSTRACT. Kafetzis, D. A., Siafas C. A., Georgakopoulos P. A., and Papadatos C. J. (Second Department of Pediatrics University of Athens, and Third Department of Obstetrics and Gynecology, Maternity Hospital “Marika Iliadi”, Athens, Greece). Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatr Scand, 70:285, 1981.–The concentrations of five cephalosporins and amoxicillin in breast milk were studied in 42 voluntarily participating lactating mothers using standard assay methods. Each mother received one single dose of 1 g of either an orally or intravenously administered antibiotic. Amoxicillin, cephalexin , and cefadroxil were given orally, and peak milk concentrations averaged 0.81±0.33 µg/ml at 5 hours, 0.50±0.23 ug/ml at 4 hours, and 1.64±0.73 µg/ml at 6 hours, respectively. Cephalothin, cephapirin and cefotaxime were given as an i.v. bolus injection, and peak milk concentrations at 2 hours averaged 0.47±0.14 ug/ml, 0.43±0.16 µg/ml and 0.32±0.09 ug/ml, respectively. The high concentrations of cefadroxil can be explained by its low rate of elimination and higher fat solubility. Milk/serum ratios for all antibiotics were increasing as serum concentrations were diminishing, especially with cephalothin and cephapirin whose serum concentrations are rapidly declining. The significance of bactericidal concentrations in breast milk remains to be evaluated.