Premium
SENSITIVITY TO EXOGENOUS INSULIN and RELEASE OF ENDOGENOUS INSULIN IN HYPOPITUITARY NON‐HYPOGLYCEMIC CHILDREN TREATED WITH HGH
Author(s) -
CICOGNANI A.,
SALARDI S.,
MAZZANTI L.,
CACCIARI E.,
PIRAZZOLI P.,
ZAPPULLA F.,
BERNARDI F.,
BERGAMASCHI R.
Publication year - 1981
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1981.tb07172.x
Subject(s) - medicine , insulin , endocrinology , diabetes mellitus , glucose tolerance test , insulin tolerance test , insulin sensitivity , insulin resistance
. Cicognani, A., Salardi, S., Mazzanti, L., Cacciari, E., Pirazzoli, P., Zappulla, F., Bernardi, F. and Bergamaschi, R. (The Department of Paediatrics, University of Bologna, Italy). Sensitivity to exogenous insulin and release of endogenous insulin in hypopituitary non‐hypoglycemic children treated with hGH. Acta Paediatr Scand, 70:47, 1980.–Twenty‐one prepubertal patients treated with hGH for periods ranging from 5 to 62 months, 5 untreated prepubertal patients and 12 normal, prepubertal patients were examined. All were given an oral glucose tolerance test with blood glucose determination and continuous i.v. glucose tolerance test with measurement of blood glucose and insulin. In the latter test the integrals of the blood glucose and insulin curves were calculated. The treated patients were also divided into groups on the basis of their height age/weight age ratio (<1 and >1), chronological age (under 10 and over 10 years) and type of deficiency (isolated or multiple). 15 of the 21 treated patients underwent an insulin test after various treatment periods and again one month after suspension of the treatment. The integrals of the curves for fall in glucose, the maximum per cent fall in glucose and the minimum glucose level attained were calculated. Two of the 21 patients showed chemical diabetes in the oral glucose tolerance test. The average glucose levels after the oral test for the treated and untreated patients, subdivided and not into groups according to chronological age, height age/weight age ratio and isolated or associated deficiency, did not differ from those of the control group. The glucose‐curve integrals for the i.v. test were higher in the treated patients who were over 10 years. The average value of the insulin‐curve integrals for the normal patients was higher than that for the whole group of treated patients, than the untreated group and than the treated, hypopituitary patients with an isolated GH deficiency. The average insulin‐curve integrals for the patients with a height age/weight age ratio <1 were higher than that for patients with a ratio >1. The normal patients with a ratio ‐ 1 showed higher values than those with a ratio 1. The last two groups showed higher values than those for the analogous groups of treated patients. The integral for the treated patients over 10 years was less than that for the analogous group of normal patients. The average integrals for the curve expressing fall in glucose during the insulin test, just as for the maximum per cent fall, did not change significantly after the therapy was suspended. The minimum glucose level reached during the test performed one month after the suspension of therapy was lower than that determined during treatment.