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DEFECT IN BILE ACID CONCENTRATING ABILITY OF THE GALLBLADDER IN CONGENITAL CHLORIDE DIARRHOEA
Author(s) -
BAKKEREN J.,
MONNENS L.,
OS C. VAN
Publication year - 1981
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1981.tb07171.x
Subject(s) - medicine , gallbladder , gastroenterology , chloride , bile acid , metallurgy , materials science
. Bakkeren, J., Monnens, L. and van Os, C. (Departments of Paediatrics and Physiology, University of Nijmegen, Nijmegen, The Netherlands). Defect in bile acid concentrating ability of the gallbladder in congenital chloride diarrhoea. Acta Paediatr Scand, 70:43, 1981.–Congenital chloride diarrhoea is assumed to be caused by a defect in the coupled NaCl influx mechanism in the ileum. As a similar coupled NaCl transport mechanism has been postulated in the gallbladder, the concentrating ability of the gallbladder was studied in a patient with congenital chloride diarrhoea. Bile acid concentrations were measured in the duodenal fluid before and after stimulation of gallbladder contraction by cholecysto‐kinin. In the chloride‐diarrhoea patient no increase in bile acid concentration was established after cholecystokinin injection, in contrast to a pronounced increase in three control children, suggesting that the absorption of salt and water by the gallbladder may be disturbed in the patient. The results support the postulated similarity of the NaCl transport mechanisms in the ileum and gallbladder. In congenital chloride diarrhoea one defect in a NaCl transport protein could explain the disturbances in electrolyte absorption.