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METABOLIC EFFECTS OF OBSTETRIC REGIONAL ANALGESIA AND OF ASPHYXIA IN THE NEWBORN INFANT DURING THE FIRST TWO HOURS AFTER BIRTH: II. Arterial Plasma Concentrations of Glycerol, Free Fatty Acids and Beta‐hydroxybutyrate
Author(s) -
SWANSTRÖM S.,
BRATTEBY L.E.
Publication year - 1981
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1981.tb06231.x
Subject(s) - medicine , asphyxia , anesthesia , lidocaine , perinatal asphyxia , physiology
. Swanstrom, S. and Bratteby, L.‐E. (Perinatal Research Unit of the Department of Paediatrics and the Unit of Paediatric Physiology of the Department of Clinical Physiology, University Hospital, Uppsala, Sweden). Metabolic effects of regional analgesia and of asphyxia in the newborn infant during the first two hours after birth. II. Arterial plasma concentrations of glycerol, free fatty acids and beta‐hydroxybutyrate. Acta Paediatr Scand, 70: 801, 1981.‐Effects of obstetric regional analgesia and of asphyxia on the arterial blood concentrations of the lipid metabolites: glycerol, free fatty acids and beta‐hydroxybutyrate were investigated in 85 newborn infants divided into a control group, an asphyxia group, a continuous epidural, an intermittent epidural and a paracervical + pudendal block group; lidocaine was the drug used in the analgesia groups. The postnatal changes in lipid metabolites followed three different patterns. After marked increases in glycerol and free fatty acids a steady level was reached after one hour in the control group and not before two hours in the regional analgesia groups. In the asphyxia group, however, a steady level was found already 10 min after birth. Between 30 and 120 min after birth the beta‐hydroxybutyrate concentration increased in the control group, decreased in the asphyxia group and did not change in the three regional analgesia groups. The different patterns of lipid metabolites may indicate differences in sympathetic tone and/or in hormonal influences after birth.