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ENZYME STUDIES AND NEONATAL BRAIN DAMAGE
Author(s) -
DALENS B.,
VIALLARD J. L.,
RAYNAUD E. J.,
DASTUGUE B.
Publication year - 1981
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1981.tb05779.x
Subject(s) - medicine , lactate dehydrogenase , creatine kinase , psychomotor learning , cerebrospinal fluid , brain damage , enzyme , pediatrics , physiology , biochemistry , psychiatry , cognition , chemistry
. Dalens, B, Viallard, JL, Raynaud, EJ, Dastugue, B. (Département d'Anesthésie‐Réanimation, Laboratoire de Biochimie Médicale et Enzymologie, Clinique Médicale Infantile, Hotel‐Dieu, Clermont‐Ferrand, France). Enzyme studies and neonatal brain damage. Acta Paediatr Scand, 70:743,.–The authors report a double‐blind study of 57 full‐term newborn infants prospectively subjected to clinical, electroencephalographical, blood and cerebrospinal fluid, and developmental examinations. Four enzymatic activities were measured in blood and CSF: aminotransferase (ASAT), creatine kinase (CK), lactate dehydrogenase (LD) and hydroxybutyrate dehydrogenase (HBD). Close relationships of enzymatic levels with psychomotor outcome are reported. In blood, ASAT and CK seemed to be the most important determinations, allowing threshold‐values to be suggested. In CSF, LD and HBD were the determinations the most closely related to psychomotor events at age one. This method seems to be of theoretical as well as practical importance in evaluating neonatal brain injury.