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ADDISON'S DISEASE ASSOCIATED WITH PRECOCIOUS SEXUAL DEVELOPMENT IN A BOY
Author(s) -
MARILUS R.,
DICKERMAN Z.,
KAUFMAN H.,
VARSANO I.,
LARON Z.
Publication year - 1981
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1981.tb05748.x
Subject(s) - medicine , precocious puberty , addison's disease , delayed puberty , bone age , sex organ , testosterone (patch) , pediatric endocrinology , pediatrics , disease , endocrinology , hormone , biology , genetics
. Marilus, R., Dickerman, Z., Kaufman, H., Varsano, I. and Laron, Z. (Institute of Pediatric and Adolescent Endocrinology, Steroid Laboratory and Pediatric Department B, Beilinson Medical Center, Petah Tikva, Sackler School of Medicine, Tel Aviv University, Israel). Addison's disease associated with precocious sexual development in a boy. Acta Paediatr Scand, 70:587,.–An eleven‐year‐old boy was diagnosed to have Addison's disease with an ACTH level of over 4 500 pg/ml after a short episode of fever and dehydration. From the age of 6 years his skin and buccal mucosa had been hyperpigmented but there were no other subjective complaints. The clinical examination also revealed signs of advanced puberty for his age (3rd‐4th stage according to Tanner's criteria), with advanced bone age (13 years). The elevated levels of plasma testosterone and gonadotropins and their response to LH‐RH stimulation were appropriate for his clinical stage of puberty and supported the diagnosis of true precocious puberty. It is proposed that the concomitant appearance of Addison's disease and precocious puberty is due to a “drift” phenomenon of LH‐RH and/or gonadotropins following the prolonged elevation of ACTH secretion.