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B‐CELL RESPONSE TO EXERCISE IN DIABETIC AND NON‐DIABETIC CHILDREN
Author(s) -
HEDING L. G.,
LUDVIGSSON J.
Publication year - 1980
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1980.tb15315.x
Subject(s) - proinsulin , medicine , c peptide , endocrinology , insulin , diabetes mellitus , endogeny , rest (music) , physical exercise
. Heding, L. G. and Ludvigsson, J. (Novo Research Institute, DK‐2880 Bagsvaerd, Denmark and the Department of Pediatrics, Linköping University, S‐581 85 Linköping, Sweden). B‐cell response to exercise in diabetic and non‐diabetic children. Acta Pediatr Scand, Suppl. 283: 57, 1980.—20 non‐diabetic and 11 insulin dependent diabetic (IDD) children underwent short time (20 min) bicycle ergometer exercise followed by a 10 min rest period. Glucose, IRI, C‐peptide and proinsulin were determined prior to and at the end of the exercise, and again after 10 min rest. While no significant change in mean glucose was observed during exercise in the non‐diabetics, significant decreases were observed in IRI, C‐peptide and proinsulin. After 10 min rest glucose as well as the three B‐cell secretory products increased significantly. The change in glucose was Significantly ( p <0.001) correlated to the change in IRI. In the resting period IRI rose more than C‐peptide in some subjects. IRI even rose without simultaneous rise in C‐peptide indicating a release of tissue bound IRI. The group of IDD children did not show any significant changes in glucose and total IRI, while the endogenous insulin, as measured by C‐peptide, did show a fall during exercise. The same was found for proinsulin. The lack of increased endogenous secretion during the rest period was most likely due to suppression of B‐cell due to hyperinsulinism and lack of increased glucose concentrations during the rest period.