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NEUTROPHIL CHEMOTACTIC DEFECT AND HYPOGAMMAGLOBULINEMIA
Author(s) -
LORENTE F.,
FONTAN G.,
RODRIGUEZ M. C. GARCÍA,
ALBA J.,
OJEDA J. A.
Publication year - 1980
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1980.tb07349.x
Subject(s) - hypogammaglobulinemia , medicine , chemotaxis , immunology , antibody , receptor
. Lorente, F., Fontán, G., García Rodriguez, M. C., Alba, J. and Ojeda, J. A. (Service of Immunoallergy, Department of Paediatrics and Department of Pathology, La Paz Hospital, Madrid, Spain). Neutrophil chemotactic defect and hypogammaglobulinemia. Acta Paediatr Scand, 69:699, 1980.—A 15‐months‐old boy developed agranulocytosis after administration of Chloramphenicol and Amynopirine. In spite of total hematological recovery, the patient's immunological study disclosed a persistent neutrophil chemotactic defect and hypogammaglobulinemia. Other studies of specific and non‐specific immunity were normal. Neutrophil adherence, random and random stimulated mobility were always within the normal range. The presence of chemotactic inhibitors was discarded. In vitro incubation of his neutrophils with Cytochalasin B at 0.1 µg/ml final concentration, reversed the chemotactic abnormality suggesting a possible cell membrane defect.