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β 2 ‐MICROGLOBULIN IN CEREBROSPINAL FLUID FROM CHILDREN WITH DIFFERENT DISEASES
Author(s) -
IBSEN K. KAAS
Publication year - 1980
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1980.tb07334.x
Subject(s) - medicine , beta 2 microglobulin , cerebrospinal fluid , paresis , meningitis , prospective cohort study , gastroenterology , pediatrics , surgery
. Kaas Ibsen, K. (The University Clinic of Paediatrics, Children's Hospital Fuglebakken, Copenhagen, Denmark). β 2 ‐microglobulin in cerebrospinal fluid from children with different diseases. Acta Paediatr Scand, 69: 633, 1980.—β 2 ‐microglobulin concentrations in cerebrospinal fluid (CSF) were measured in a prospective study on 56 children 0–12 years old. In all the patients with virus meningitis values of β 2 ‐microglobulin exceeded 3000 µg/l (x̄=10.825 µg/l). The highest value (48.096 µg/l) of β 2 ‐microglobulin in CSF was found in a 13‐day‐old infant with serious herpes simplex meningitis. The value was 50 times the values found in normal children. None of the patients with fever of other origin had values exceeding 3500 µg/l, except for one patient with facial nerve paresis and 3 patients with sepsis. Some correlation between the concentrations of β 2 ‐microglobulin and albumin was found in the diagnostic groups as a whole, while this correlation disappeared when considering each patient individually. The significance of β 2 ‐microglobulin as a guide in serious infections is discussed.