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ARTIFICIAL VENTILATION OF PREMATURE NEWBORN RABBITS; EFFECTS OF POSITIVE END‐EXPIRATORY PRESSURE ON LUNG MECHANICS AND LUNG MORPHOLOGY
Author(s) -
NILSSON R.,
GROSSMANN G.,
ROBERTSON B.
Publication year - 1980
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1980.tb07328.x
Subject(s) - medicine , lung , ventilation (architecture) , positive end expiratory pressure , mechanical ventilation , artificial ventilation , parenchyma , pulmonary compliance , respiratory physiology , tidal volume , anesthesia , respiratory disease , respiratory system , pathology , mechanical engineering , engineering
. Nilsson, R., Grossmann, G. and Robertson, B. (Department of Paediatric Pathology and Department of Paediatrics, St. Goran's Children's Hospital, Karolinska Institutet, Stockholm, Sweden). Artificial ventilation of premature newborn rabbits; effects of positive end‐expiratory pressure on lung mechanics and lung morphology. Acta Paediatr Scand, 69: 597, 1980.—44 premature newborn rabbits, removed by hysterotomy on day 27 of gestation, were ventilated with positive pressure under differing standardized conditions, with or without application of positive end‐expiratory pressure (PEEP; 5 cm H 2 O). After 10 min ventilation, compliance of the lung‐thorax system was significantly higher in fetuses ventilated with PEEP than in controls. The application of PEEP also resulted in a significantly lower maximal expiratory air flow compared to controls in groups ventilated with standardized tidal volume. Morphometric evaluation revealed bronchiolar epithelial lesions to be less prominent in fetuses treated with PEEP. Our findings show that application of PEEP has a beneficial effect on lung mechanics during artificial ventilation and that it reduces the risk of epithelial damage to the airways, presumably by promoting uniform expansion of the lung parenchyma.