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AUTOANTIBODIES TO TAMM‐HORSFALL GLYCOPROTEIN IN CHILDREN WITH RENAL DAMAGE ASSOCIATED WITH URINARY TRACT INFECTIONS
Author(s) -
FASTH A.,
BJURE J.,
HELLSTRÖM M.,
JACOBSSON B.,
JODAL U.
Publication year - 1980
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1980.tb07138.x
Subject(s) - medicine , urinary system , autoantibody , antibody , creatinine , renal function , tamm–horsfall protein , immunology , gastroenterology
Abstract. Fasth, A., Bjure, J., Hellström, M., Jacobsson, B. and Jodal, U. (Departments of Pediatrics, Clinical Immunology, Pediatric Clinical Physiology and Pediatric Radiology). Autoantibodies to Tamm‐Horsfall glycoprotein in children with renal damage associated with urinary tract infections. Acta Paediatr Scand, 69: 709, 1980.—Autoantibodies to the Tamm‐Horsfall (TH) protein were analyzed in sera from 116 patients with pyelonephritis. The increases in antibody levels were limited in 23 patients with radiological detected renal damage during 31 attacks of acute pyelonephritis. 8 children with abnormally low total and/or unilateral 51 Cr EDTA clearance had significantly lower IgG antibody levels to TH protein, than 14 children with normal clearance rate. All 61 children with renal damage had significantly low IgG, IgA and IgM antibody levels to TH protein 6 months after last infection as compared to the reference group. For IgG antibodies, the mean was well below –2 S.D. 12 children with increased serum creatinine had significantly lower IgG antibody levels than those with normal creatinine. No correlation was found between antibody levels and vesico‐ureteric reflux. In contrast, 55 children with no renal damage still had significantly increased IgG and IgA antibody levels to TH protein 6 months after the infection. The mechanism for the low antibody levels was discussed and it was concluded that patients with urinary tract infection and low IgG antibody levels to TH protein were at risk for renal damage and should be radiologically examined.