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INACTIVATED POLIOVACCINE: ADVERSE REACTIONS AND ANTIBODY RESPONSES
Author(s) -
RUUSKANEN OLLI,
SALMI TOIVO T.,
STENVIK MIRJA,
LAPINLEIMU KAISA
Publication year - 1980
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1980.tb07099.x
Subject(s) - medicine , antibody , adverse effect , immunology , virology , intensive care medicine
. Ruuskanen, O., Salmi, T. T., Stenvik, M. and Lapinleimu, K. (Department of Paediatrics, University of Turku, and the Central Public Health Laboratory, Helsinki, Finland). Inactivated poliovaccine: adverse reactions and antibody responses. Acta Paediatr Scand, 69:397, 1980.—Adverse reactions and antibody responses after inactivated poliovaccine were studied in 380 children. Fever reaction (≥37.5°C rectally) was recorded in 14% of children after the first poliovirus vaccination and in 19% after the second. Restlessness was reported in 15 % and 14 % of the children. Fever reaction exceeding 38.5°C was seen in 5% of the vaccines. Before the first vaccination at the age of six months 29% of the 48 children had antibodies against poliovirus types 1 and 2 and 43% against type 3. The first vaccination induced no significant changes in antibody titers. After the second vaccination antibody responses were low and 35%, 9%, and 35% remained seronegative to types 1, 2 and 3, respectively. After the third vaccination at the age of two years the respective geometric mean titers were 1:67, 1: 335 and 1:48. No measurable antibodies were found to type 1 in 23%, to type 2 in 2%, and to type 3 in 10%. Only one child was triplenegative. All seronegative children were revaccinated and in all vaccinees a seroconversion ocurred two weeks after the booster dose. The combination of inactivated poliovaccine to DPT (Diphtheria, Tetanus, Pertussis) vaccine induced no significant change in poliovirus antibodies or in adverse reactions.