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ENHANCED RENAL TUBULAR CALCIUM REABSORPTION INDEPENDENT OF PARATHORMONE ACTIVITY, IN CHILDREN ON LONG TERM ANTICONVULSANT THERAPY
Author(s) -
ALADJEM M.,
SHOHAT M.,
ORDA S.,
BOICHIS H.
Publication year - 1980
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1980.tb07084.x
Subject(s) - medicine , calcium , urinary system , endocrinology , reabsorption , alkaline phosphatase , creatinine , urinary calcium , excretion , anticonvulsant , renal physiology , renal function , kidney , epilepsy , chemistry , biochemistry , enzyme , psychiatry
. Aladjem, M., Shohat, M., Orda, S., and Boichis, H. (Pediatric Renal Unit, Chaim Sheba Medical Center, Tel Hashomer, and the Sadder School of Medicine, Tel‐Aviv University, Israel). Enhanced renal tubular calcium reabsorption, independent of parathormone activity, in children on long term anticonvulsant therapy. Acta Paediatr Scand, 69: 311, 1980.—A significant reduction in the urinary calcium‐creatinine ratio, was found in thirty‐four ambulatory epileptic children on long term anticonvulsant therapy, studied during wintertime. No significant difference in the urinary excretion of cyclic AMP, phosphate or amino‐acids was observed when the study‐group was compared to an age‐matched control group. Serum calcium and phosphate values were normal, but a significant increment in alkaline phosphatase was noted. Since there was no evidence of hyperactivity of the parathormone, it is suggested that the enhanced renal tubular calcium reabsorption in children on long term anticonvulsant therapy is a nonparathormone mediated phenomenon, possibly compensating for reduced calcium absorption in the gastrointestinal tract.