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HYPERTHYROIDISM, DIABETES MELLITUS AND THE CONGENITAL RUBELLA SYNDROME
Author(s) -
FLORET D.,
ROSENBERG D.,
HAGE G. N.,
MONNET P.
Publication year - 1980
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1980.tb07073.x
Subject(s) - medicine , congenital rubella syndrome , diabetes mellitus , pediatrics , rubella , endocrinology , virology , measles , vaccination
. Floret, D., Rosenberg, D., Hage, G. N. and Monnet, P. (Clinique Médicate Infantile B, Hopital E. Herriot, Lyon, France). Hyperthyroidism, diabetes mellitus and congenital rubella syndrome. Acta Paediatr Scand, 69: 259, 1980.—A male patient born to a mother who developed rubella during the tenth week of gestation presented a typical congenital rubella syndrome with mental retardation, neuro‐sensory deafness, hypoplasia of the dental enamel and chorioretinitis. Hyperthyroidism occurred at the age of 3 10/12 years and was treated successfully with propylthiouracil for 4 years. The course was complicated by premature craniosynostosis and a craniectomy was performed at the age of 7 years. Overt diabetes mellitus developed at 17 years and was well controlled by insulin therapy. Histocompatibility (HLA) antigens were A2, B8, B40. Diabetes mellitus and thyroid disorders have previously been reported after congenital rubella, and recently after congenital cytomegalovirus infection. Our patient had both endocrinopathies. It is possible that HLA B8 antigens might be responsible for increased susceptibility to rubella infection.