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PLASMA SECRETIN IN NEONATES
Author(s) -
LUCAS A.,
ADRIAN T. E.,
BLOOM S. R.,
AYNSLEYGREEN A.
Publication year - 1980
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1980.tb07061.x
Subject(s) - secretin , medicine , basal (medicine) , plasma levels , endocrinology , plasma concentration , enteral administration , insulin , pediatrics , parenteral nutrition , pancreas
. Lucas, A., Adrian, T. E., Bloom, S. R. and Aynsley‐Green, A. (University Department of Paediatrics, John Radcliffe Hospital, Oxford and Hammersmith Hospital, London). Plasma secretin in neonates. Acta Paediatr Scand, 69: 205, 1980.—Plasma secretin has been measured in 96 normal 6‐day‐old term infants and in 158 healthy preterm infants whose mean post‐partum ages were 2½, 6, 13 or 24‐days. At birth, plasma secretin levels in both term and preterm infants were high compared with those seen in healthy fasting adults ( p > 0.001), but subsequently declined towards adult values. In contrast, preterm infants who had not been fed for the first 6 days of life, had presistently high basal plasma secretin values. In term infants at 6 days of age and in preterm infants up to 13 days, there was no se‐cretin response to a feed. However, by 24 days, preterm infants showed a marked post‐prandial secretin elevation ( p > 0.02). No correlations were found between plasma secretin concentrations and either blood glucose or plasma insulin concentrations following a feed. Significant adjustments in plasma secretin levels occur in the early weeks of life which may be influenced by enteral feeding.