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POST‐NATAL DEVELOPMENT OF FACTOR IX
Author(s) -
SCHETTINI F.,
MATTIA D. De,
ALTOMARE M.,
MONTAGNA O.
Publication year - 1980
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1980.tb07029.x
Subject(s) - medicine , factor ix , clotting factor , antigen , vitamin , immunoelectrophoresis , physiology , endocrinology , immunology
. Schettini F., De Mattia D., Altomare M. and Montagna O. (University of Bari, Institute of Child Health, Bari, Italy). Postnatal development of factor IX. Acta Paediatr Scand, 69: 53, 1980.—Post‐natal development of clotting activity and of antigen level of Factor IX was evaluated in 111 healthy, breastfed, newborn infants, aged 1–30 days. Of these, 80 had received at birth 2 mg of vitamin K 1 orally. Factor IX clotting activity was determined by one‐stage assay and antigen level by electroimmunoassay. On the 1st day both antigen level and clotting activity were low and the ratio was 1.01. There was a significant postnatal increase of the two activities of Factor IX during the first three days of life; thereafter both remained constant. No statistical difference in Factor IX activity was found with oral administration of vitamin K 1 after the birth. During the first month of life both clotting activity and antigen level of Factor IX were low as compared to adult values. There was no correlation with age. The Factor IX protein of newborns did not show molecular heterogeneity by crossed‐immunoelectrophoresis