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IMMUNOCOMPETENCE IN OBESITY
Author(s) -
CHANDRA R. K.,
KUTTY K. M.
Publication year - 1980
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1980.tb07024.x
Subject(s) - immunocompetence , medicine , obesity , immunology , immune system
. Chandra, R. K. & Kutty, K. M. (Department of Pediatrics, Memorial University of Newfoundland, St. John's, Newfoundland, Canada). Immunocompetence in obesity. Acta Paediatr Scand 69:25, 1980.—Thirty‐eight % of obese children and adolescents showed a variable impairment of cell‐mediated immune responses in vivo and in vitro and reduction of intracellular bacterial killing by polymorphonuclear leukocytes. The obese group had a higher incidence of iron deficiency and moderately lower serum zinc concentrations. Levels of serum immunoglobulins, complement components C3 and C4, and numbers of T and B lymphocytes were comparable in the two groups. Serum triglycerides, cholesterol and lipoproteins were normal in all subjects. Immunologic changes correlated with the presence of subclinical deficiencies of iron and zinc. Therapy with these micronutrients for 4 weeks resulted in improvement in immunologic responses