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INCREASED OSMOTIC FRAGILITY OF ERYTHROCYTES IN CHRONICALLY JAUNDICED RATS AFTER PHOTOTHERAPY
Author(s) -
CUKIER JULIO O.,
MAGLALANG APOLO C.,
ODELL GERARD B.
Publication year - 1979
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1979.tb08231.x
Subject(s) - erythrocyte fragility , irradiance , fragility , medicine , hemolysis , in vivo , endocrinology , biology , chemistry , optics , genetics , physics
. Littermate homozygous (jj) and heterozygous (Jj) Gunn rats, were irradiated with blue fluorescent light for 18 hours continuously. The incident irradiance was 1.5 mWatts/cm 2 in the 420–480 nm band pass. The influence of the irradiance on circulating erythrocytes was studied by testing their osmotic fragility before and after the irradiance. The non‐jaundiced, Jj, animals did not exhibit any increase in the osmotic fragility of their erythrocytes. The osmotic fragility of the erythrocytes from jaundiced, Jj, animals was the same as the Jj animals prior irradiance. However, the fragility of the erythrocytes from the jj animals was significantly increased after the 18 hours of irradiance. The results indicate that the photodynamic action of bilirubin may be present in vivo.