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DEALING WITH SUSPICIONS OF MALFORMATION FREQUENCY INCREASE: Experience with the Swedish Register of Congenital Malformations
Author(s) -
KÄLLÉN B.,
WINBERG J.
Publication year - 1979
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1979.tb06163.x
Subject(s) - medicine , congenital malformations , register (sociolinguistics) , incidence (geometry) , pediatrics , cohort , variation (astronomy) , etiology , cohort study , pregnancy , pathology , philosophy , linguistics , genetics , physics , optics , biology , astrophysics
. Källén, B. and Winberg, J. (Department of Embryology, University of Lund and Department of Paediatrics at the Karolinska Hospital, Karolinska Institute, Stockholm). Dealing with suspicions of malformation frequency increase, Experiences with the Swedish Register of Congenital Malformations. Strategies in dealing with data obtained from malformation monitoring based on experiences with the Swedish monitoring systems, operating since 1965 (Register of Congenital Malformations) and 1973 (Medical Birth Register) are discussed. The importance of checking data that have sounded an alarm is stressed. Experience has shown that false alarms due to artefacts, such as changed diagnostic routines, changed reporting or registration of malformations, or random fluctuations, comprise most suspected changes in incidence. If a true increase in malformation frequency or a local cluster is observed, a hint of possible aetiological factors can be obtained from studies of maternal age distribution, seasonal variation, geographical distribution, etc. The last step of the analysis consists of a case‐control or a cohort study, aimed at revealing a specific teratogen. The importance of locating limited research resources to well‐defined problems using high quality data is stressed.