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NONKETOTIC HYPERGLYCINEMIA Clinical, Biochemical and Therapeutic Aspects
Author(s) -
KØLVRAA S.,
BRANDT N. J.,
CHRISTENSEN E.
Publication year - 1979
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1979.tb05072.x
Subject(s) - hyperglycinemia , medicine , strychnine , glycine , presentation (obstetrics) , depression (economics) , pediatrics , surgery , pharmacology , biochemistry , amino acid , chemistry , economics , macroeconomics
. A patient exhibiting progressive cerebral depression from the first days of life is described. The diagnosis of nonketotic hyperglycinemia was established on the typical clinical presentation, elevated glycine concentrations in body fluids and diminished glycine cleavage activity in liver tissue. A series of therapatic trials, including strychnine treatment, was tried on this patient without apparent effect on the clinical course.