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ELECTROLYTE ABNORMALITIES IN LYMPHOSARCOMA AFTER CHEMOTHERAPY
Author(s) -
TZORTZATOU F.,
DACOUVOUTETAKIS C.,
HAIDAS S.,
PAPADELLIS F.,
THOMAIDIS TH.
Publication year - 1979
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1979.tb05069.x
Subject(s) - medicine , antidiuretic , chemotherapy , malignancy , vincristine , cyclophosphamide , alkalosis , endocrinology , hormone , vasopressin , gastroenterology , acidosis
. A 12‐year‐old female with lymphosarcoma responding to treatment including vincristine and cyclophosphamide developed clinical and laboratory findings compatible with the syndrome of inappropriate secretion of antidiuretic hormone. Some additional findings were observed, i.e. uremia, hypopotassemia and alkalosis, that have not so far been recorded in that syndrome. All abnormalities were corrected upon water restriction. A similar episode occurred after a 2nd drug course. It too was corrected upon water restriction. The patient was clinically free from her malignancy in both episodes. It is suggested that our child had probably an expanded form of the syndrome of inappropriate secretion of antidiuretic hormone.