Premium
DISSEMINATED HERPES SIMPLEX VIRUS INFECTION IN ATAXIA‐TELANGIECTASIA
Author(s) -
BENZVI A.,
SOFFER D.,
YATZIV S.
Publication year - 1978
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1978.tb17821.x
Subject(s) - herpes simplex virus , ataxia telangiectasia , medicine , virus , virology , immune system , ataxia , immunology , antibody , biology , dna , genetics , psychiatry , dna damage
. The clinical and pathological features are described in a child with ataxia‐telangiectasia, complicated by fatal disseminated herpes simplex virus infection. Herpes simplex virus was isolated from the patient's blood, and the histopathological findings in the skin, liver and adrenals were consistent with herpes simplex virus infection. The patient had a combined immune deficiency state, as a part of the ataxia‐telangiectasia syndrome. She had impaired cellular immune response to herpes simplex virus and developed no antibodies against the virus. To our knowledge, this is the first fatal case of disseminated herpes simplex virus infection in ātaxia‐telangiectasia.