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THE ABSENCE OF FACTOR II IN A CHILD WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Author(s) -
LILLQUIST K. B.,
DYERBERG J.,
KROGHJENSEN M.
Publication year - 1978
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1978.tb16366.x
Subject(s) - medicine , prednisone , azathioprine , diathesis , lupus erythematosus , systemic lupus erythematosus , immunology , plasma levels , systemic lupus , bleeding diathesis , antibody , disease , platelet
. This report describes a patient with active systemic lupus erythematosus (SLE), who developed haemorrhagic diathesis due to a lowering of plasma factor II activity. No evidence was found suggesting a plasma inhibitor of factor II. The present case indicates that in some patients with SLE, factor II activity may be low or completely absent due to impairment of factor II synthesis, further that prednisone, but not azathioprine, may ameliorate this defect.