Premium
RENAL FUNCTION IN ANOREXIA NERVOSA
Author(s) -
APERIA A.,
BROBERGER O.,
FOHLIN L.
Publication year - 1978
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1978.tb16306.x
Subject(s) - anorexia nervosa , medicine , renal function , psychiatry , eating disorders , endocrinology
. Renal function was examined in twelve patients, eight girls and four boys, with anorexia nervosa (AN) ranging in age from 12.6 to 18.2 years. The weight loss at the time of the study averaged 26%. Determinations were made of glomerular filtration rate (GFR), PAH clearence (C PAH ) and urinary concentrating capacity. For references the same studies were also carried out in five healthy teenagers. Both GFR and C PAH were generally reduced in AN. The reduction of GFR was, however, out of proportion to the reduction of C PAH as shown by a significantly lower filtration fraction (FF) in AN. Indirect evidence suggests that the low FF could be attributed to reduced water permeability of the glomerular capillary. The urinary concentrating capacity following fluid deprivation was moderately depressed both before and after the administration of vasopressin. The concentrating defect in AN must therefore be primary of renal origin.