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BRAIN‐TYPICAL CREATINEKINASE IN THE SERUM OF NEWBORN INFANTS WITH PERINATAL BRAIN DAMAGE
Author(s) -
BECKER M.,
MENZEL K.
Publication year - 1978
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1978.tb16299.x
Subject(s) - medicine , brain damage , proband , agar gel , pathological , physiology , pathology , biochemistry , microbiology and biotechnology , chemistry , biology , mutation , gene
. Abnormal values of serum‐CK‐activity in healthy newborns varied greatly (95% range: 4–165 U/l; 257 probands) and the borderline to pathological values was not sharp. Brain‐typical CK‐isoenzyme (CK‐BB) could be detected in serum of 6 of 8 infants with perinatal brain damage by means of agar gel electrophoresis. The combination of neuropathological symptoms, increased total‐serum‐CK‐activity, and significant amount of CK‐BB in serum seemed to be a sure sign of severe CNS‐damage in newborns.