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FACTOR VIII ACTIVITY AND ANTIGEN IN SICK NEWBORNS WITH PATHOLOGICAL PROTEOLYSIS IN BLOOD
Author(s) -
HENRIKSSON P.,
HOLMBERG L.
Publication year - 1978
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1978.tb16281.x
Subject(s) - medicine , proteolysis , pathological , sick child , antigen , immunology , pediatrics , biochemistry , enzyme , chemistry
. Factor VIII clotting activity (VII:C) and factor VIII related antigen (VIII:R:AG) were determined in 12 sick newborn infants with pathological proteolysis in their circulation. A marked discrepancy was noted between VIII:R:AG and VIII:C, the ratio in sick infants being, on average, 2: 1, while no discrepancy was seen in healthy newborns. The finding in the sick infants resembled a low grade plasminogen activation, which was studied experimentally. It is concluded that demonstration of a marked discrepancy between VIII: R: AC, and VIII:C is a useful indication of pathological proteolysis in sick newborns.