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DIABETIC VASCULAR DISEASE:The Importance of Insulin Deficiency, Hyperglycemia and Hypophosphatemia on Red Cell Oxygen Unloading 1
Author(s) -
DITZEL JØRN
Publication year - 1977
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1977.tb15131.x
Subject(s) - medicine , hypophosphatemia , endocrinology , hypertriglyceridemia , hypoxia (environmental) , diabetes mellitus , diabetic angiopathy , red cell , insulin , oxygen , triglyceride , chemistry , organic chemistry , cholesterol
. Diabetes is associated with a fluctuating impairment in oxygen transport of the erythrocytes. This impairment is correlated with hyperglycemia by the formation of glycosylated hemoglobin (HbA 1c ) and with inhibitory factors of glycolysis i.e. hypophosphatemia and acidosis which lower the concentration of red cell 2,3‐diphosphoglycerate. Diabetic angiopathy may be the ultimate result of innumerable microvascular responses to discrete hypoxic injuries associated with increased plasma permeation through the vessel walls. It is shown that two additional risk factors for atherosclerosis—smokg and hypertriglyceridemia may also lead to arterial wall hypoxia by changing the position of the oxyhemoglobm dissociation curve.