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MONOZYGOTIC TWINS CONCORDANT FOR TRACHEO‐ESOPHAGEAL FISTULA AND DISCORDANT FOR THE VATER ASSOCIATION
Author(s) -
KING SUSANNE L.,
LADDA R. L.,
SHOCHAT S. J.
Publication year - 1977
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1977.tb07989.x
Subject(s) - concordance , medicine , tracheoesophageal fistula , monozygotic twin , atresia , association (psychology) , fistula , surgery , genetics , biology , philosophy , epistemology
. Monozygotic female twins were concordant for tracheo‐esophageal fistula (TEF); and one twin also manifested other anomalies of the VATER association, including agenesis of the female reproductive tract. Review of the literature discloses a familial tendency for recurrence of TEF and a high concordance rate in monozygotic twins, indicating a significant genetic influence for the isolated anomaly. In the case of the VATER association, the sporadic occurrence of affected individuals and discordance in twins implicates the effect of non‐genetic factors.