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GONADOTROPIN‐RELEASING HORMONE (LH‐RH) AND HUMAN CHORIONIC GONADOTROPIN IN THE TREATMENT OF TWO BOYS WITH HYPOGONADOTROPHIC HYPOGONADISM
Author(s) -
KRABBE S.,
SKAKKEBÆK N. E.
Publication year - 1977
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1977.tb07908.x
Subject(s) - hypogonadotrophic hypogonadism , medicine , endocrinology , testosterone (patch) , human chorionic gonadotropin , gonadotropin , anosmia , hypogonadotropic hypogonadism , follicle stimulating hormone , hormone , luteinizing hormone , disease , covid-19 , infectious disease (medical specialty)
. Two brothers, 16 and 14 years of age, with hypogonadotrophic hypogonadism and anosmia were treated with subcutaneous injections of 200μg gonadotropin‐releasing hormone at 8‐hour intervals for 4 weeks. Serum FSH increased to the range of normal adult men, but serum LH and serum testosterone showed little change and no clinical signs of pubertal development occurred. Thereafter the 2 patients were given HCG for 11 months and a combination of HCG and HMG for a further 3 months. In response to this treatment, the serum testosterone levels increased to the range of normal adult men and a marked development of the secondary sex characteristics was seen.