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FACTOR XIII (FIBRIN STABILISING FACTOR) IN HENOCH‐SCHÖNLEIN'S PURPURA
Author(s) -
HENRIKSSON PER,
HEDNER ULLA,
NILSSON INGA MARIE
Publication year - 1977
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1977.tb07893.x
Subject(s) - medicine , cadaverine , antifibrinolytic , factor xiii , fibrin , purpura (gastropod) , henoch schonlein purpura , gastroenterology , von willebrand factor , tranexamic acid , surgery , immunology , vasculitis , biochemistry , enzyme , platelet , ecology , chemistry , blood loss , disease , putrescine , biology
. In 13 out of 17 consecutive children with Henoch‐Schönlein's purpura the factor XIII determined with the dansyl cadaverine method was found to be decreased during the acute phase. The decrease is assumed to be due to a specific degradation by proteolytic enzymes liberated from inflammatory cells, with defective local haemostasis as a result. This assumption is strengthened by the observation that treatment with factor XIII combined with an antifibrinolytic drug controlled life‐threatening gastro‐intestinal bleeding in one of the patients. It would therefore appear that such treatment might offer a new possibility of controlling severe haemorrhages in Henoch‐Schönlein's purpura.