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TRANSFER FACTOR AND CELLULAR IMMUNE RESPONSE IN URINARY TRACT INFECTIONS IN CHILDREN
Author(s) -
ANTTILA R.,
GRÖHN P.,
KROHN K.
Publication year - 1977
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1977.tb07836.x
Subject(s) - immune system , urinary system , medicine , transfer factor , immunology , in vitro , antigen , in vivo , stimulation , biology , biochemistry , microbiology and biotechnology
Anttila, R., Gröhn, P. and Krohn, K. (The Institute of Biomedical Sciences, School of Medicine, University of Tampere, and the Children's Department, Tampere Central Hospital, Tampere, Finland). Transfer factor and cellular immune response in urinary tract infections in children. Acta Paediatr Scand, 66:219, 1977.—Cellular immune responses in vivo and in vitro were studied in 20 children with chronic or relapsing urinary tract infections. Skin tests revealed decreased immune responses to PPD in cases with chronic or recurrent pyelonephritis and to OM, in these cases and in cases of lower urinary tract infections. Blast transformation responses to PPD, OM and PHA were at least as high as in controls. Administration of chromatographically purified fraction from human leucocyte transfer factor resulted in a positive skin reaction with antigen concentration, which before TF administration had caused a negative reaction. The results suggest that the action of the transfer factor component used in this study is based on an immunologically nonspecific stimulation of the cellular immune response.