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TRANSFER FACTOR IN CHRONIC AND RECURRENT RESPIRATORY TRACT INFECTIONS IN CHILDREN
Author(s) -
GRÖHN P.
Publication year - 1977
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1977.tb07835.x
Subject(s) - medicine , transfer factor , antigen , respiratory tract , respiratory system , immunology , respiratory tract infections
Gröhn, P. (The Institute of Biomedical Sciences, School of Medicine, University of Tampere, and the Children's Department, Tampere Central Hospital, Tampere, Finland). Transfer factor in chronic and recurrent respiratory tract infections in children. Acta Paediatr Scand, 66:211, 1977.—Five cases with abnormal sensitivity to respiratory tract infections are described. The cases showed a marked impairment in their cell mediated immunity state. Administration of a chromatographically purified transfer factor component increased the skin test sensitivity to common recall antigens. Interestingly, a similar effect in skin reactivity was observed with repeated skin tests alone, when antigen concentrations, initially high enough to cause a positive reaction, were used. Neither the administration of transfer factor nor skin testing with high antigen concentrations had an effect on blast transformation percentages. The therapy with chromatographically purified transfer factor appeared promising on the clinical condition of the patients.