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NEONATAL ACIDOSIS ASSOCIATED WITH TRANSIENT METHYLMALONICACIDURIA AND VITAMIN B12 DEFICIENCY
Author(s) -
WILLIAMS A. J.,
IRELAND J. T.
Publication year - 1977
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1977.tb07817.x
Subject(s) - methylmalonic acid , medicine , vitamin b12 , metabolic acidosis , acidosis , excretion , endocrinology , vomiting , cyanocobalamin
Investigation of a neonate presenting with a metabolic acidosis, vomiting and an apnoeic attack revealed abnormal urinary excretion of methylmalonic acid (MMA) associated with a low serum vitamin B12. Restriction of dietary protein was followed by normalisation of acid‐base balance. Reintroduction of normal daily protein intake did not precipitate further acidosis or increased excretion of MMA. The transient methylmalonicaciduria was probably due to deficiency of vitamin B12.