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LOW MOLECULAR WEIGHT ORGANIC ACIDS IN THE URINE OF THE NEWBORN
Author(s) -
GREGERSEN N.,
INGERSLEV J.,
RASMUSSEN K.
Publication year - 1977
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1977.tb07812.x
Subject(s) - creatinine , excretion , glutaric acid , adipic acid , mole , urine , citric acid , succinic acid , medicine , endocrinology , acetic acid , chromatography , chemistry , biochemistry , organic chemistry
The urinary excretion of seven selected low molecular weight organic acids in normal neonates was measured by gas chromatography. First and third to fourth day of life excretion of the following compounds was significantly unchanged: 3‐OH‐butyric acid (<13 μmol/mmol creatinine), succinic acid (approx. 43 μmol/mmol creatinine), adipic acid (approx. 12 μmol/mmol creatinine), 2‐OH‐glutaric acid (approx. 23 μmol/mmol creatinine), 3‐OH‐3‐Me‐glutaric acid (approx. 25 μmol/mmol creatinine) and citric acid (approx. 115 μmol/mmol creatinine). The excretion of 4‐OH‐phenyl‐acetic acid increased during the first four days of life (from <8 μmol/mmol creatinine to approx. 20 μmol/mmol creatinine). It is postulated that urinary organic acid excretion in the neonate, which is clearly different from the adult urinary pattern, is a reflection of the specific neonatal metabolic situation, including a high fatty acid utilisation and a low protein catabolism.